The spread and growth of so-called “superbugs” that are resistant to most antibiotics on the market, is something that hospitals and California medical malpractice lawyers are concerned about. There are fears that the number of such superbugs are likely to actually increase in the future. This indicates that there is a need for new infection-fighting strategies that don't depend solely on antibiotic therapies. Recently, one such therapy was highlighted in the journal ACS Chemical Biology. According to the report, the technique fights off infection by interfering with the ability of the pathogen to take over patient body cells.
Health organizations have already warned that unless the spread of antibiotic-resistant germs is stopped, patients will continue to be at grave risk of potentially fatal infections. Those risks are especially high in hospitals, where you have patients with weak immune systems in close proximity to all kinds of bacteria.
Most pharmaceutical approaches to fighting infections involve fighting the bacteria. The researchers,in their new strategy, focused instead on how bacteria attack the cells that they invade. The research focused on host cell proteins called kinases that can control bacterial growth. The researchers also decided to look at another class of proteins called phosphatases that act differently from kinases, to see if inhibiting these proteins would have a similar effect. They identified drugs that could inhibit the operation of phosphatases.
They found that these drugs formed a new class of antibiotics, and actually stopped the bacteria from growing. What the technique basically did was to interfere with the operation of the host cell machinery, instead of directly attacking the microbes.
The researchers believe that the findings provide a firm basis for the development of new drugs that work to fight off infections.